| Rk | Player | GS | |
|---|---|---|---|
| 1 | Nick Blackburn | 5.56 | 71 |
| 2 | Brian Matusz | 5.46 | 60 |
| 3 | John Lackey | 5.26 | 61 |
| 4 | Chris Volstad | 5.12 | 80 |
| 5 | Luke Hochevar | 5.11 | 80 |
| 6 | Jeff Francis | 5.08 | 74 |
The six starters with plus-5.00 ERA 2010-12
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