| Rk | From | To | PA | |
|---|---|---|---|---|
| 1 | Vic Willis | 1901 | 1910 | 1254 |
| 2 | Hoyt Wilhelm | 1952 | 1972 | 493 |
| 3 | Rube Marquard | 1908 | 1925 | 1196 |
| 4 | Addie Joss | 1902 | 1910 | 911 |
| 5 | Stan Coveleski | 1912 | 1928 | 1194 |
It should be noted that for Wilhelm, it was hit in his first MLB at bat. He had 493 career plate appearances in his 21-year career.
